Endocrine Abstracts

Annexin 1 (ANXA1) belongs to a well-conserved superfamily of structurally-related Ca2+ and phospholipid-binding proteins. We first described its induction and role as a mediator of glucocorticoid (GC) actions within the host defence and neuroendocrine systems. In addition we provided evidence that an extracellular pool of ANXA1 is responsible for many of the regulatory actions of the protein, particularly in the pituitary gland where ANXA1 exported from folliculoste...

Introduction: Two insulin regimes are commonly used in type 1 diabetes (T1D): twice daily (BD) premixed insulin (short and intermediate acting), and multiple daily injections (MDI) of short acting insulin with once daily bolus of long acting insulin. MDI is associated with better glucose control in adults, but the evidence base is weaker for children.Objectives: We aimed to compare children started on MDI to BD from diagnosis, on HbA1c as a measure of gl...